They also suggested the enzyme’s function in both compartments i.e., ER and the cell surface wt smears observed on SDS-PAGE, while only less than 10% portion of the enzyme reaches the cell surface. found that XCE is mostly located in the cellular endoplasmic reticulum (ER) consistent with the high mol. The physiological function of XCE was first reported from the inactivation of the corresponding gene in mice, which described the enzyme as to play a vital role in the nervous control of respiration XCE (nowadays are known as ECEL1 but we used XCE in this manuscript to differentiate with ECE-1) is expressed in the nervous system, particularly in the medulla oblongata and in the spinal cord, presumably by cholinergic neurons such as motor neurons or striatum interneurons. rodent homologue damaged-induced neuronal endopeptidase (DINE) endothelin-converting enzyme-like 1 (ECEL1) , the phosphate-regulating neutral endopeptidase on the X chromosome (PHEX) , endothelin-converting enzymes ECE-1 and ECE-2 membrane metalloendopeptidase-like 2 (MMEL2) Zinc peptidases of neprilysin family are gluzincins that include several enzymes for instance, neutral endopeptidase (NEP) is “gluzincins” which is defined by a HExxH motif including two histidines and a glutamic acid as zinc-coordinating ligands. One of the important classes of M13 family (of zinc peptidases classification according to MEROPS database) The peptide metabolism is activated by degradation of a wide range of bioactive peptides and therefore specific inhibitors of them have therapeutic values Zinc peptidases such as matrix metalloproteinases (MMPs)
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